Saturday, December 31, 2011

CapitalFM_kenya: Japan store offers $250k jewel lucky dip bag http://t.co/MRql0jtf

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Japan store offers $250k jewel lucky dip bag goo.gl/fb/jWqkA CapitalFM_kenya

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GotSagaLatino: The incredible #Roman Forum in #Rome http://t.co/rpse8Qc2 #travel #tips #Italy

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The incredible #Roman Forum in #Rome su.pr/1AgYp8 #travel #tips #Italy GotSagaLatino

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jmittell: Thunderstorm in December in Rome? Sure, why not!

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Do you know your Energy Bars? Holistic Nutrition Pt. 3 - Dec 29,2011

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Source: http://www.blogtalkradio.com/georap/2011/12/29/do-you-know-your-energy-bars-holistic-nutrition-pt-3

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Avastin can stabilize tumors in ovarian cancer, studies find

Avastin can stabilize tumors in women suffering from advanced-stage ovarian cancer, extending the period before the disease worsens by more than 3.5 months, according to the results of two large, international clinical trials conducted by separate research teams.

The findings, published in Thursday's edition of the New England Journal of Medicine, come less than a week after the European Commission approved Avastin for treating women newly diagnosed with advanced ovarian cancer. The drug, known generically as bevacizumab, has not yet been approved by the Food and Drug Administration to treat ovarian cancer in the U.S.

Though Avastin has not been shown to prolong the lives of women with ovarian cancer and does come with significant side effects, it offers some hope for treating what remains the deadliest of gynecologic cancers, researchers said.

Ovarian cancer affects an estimated 200,000 women worldwide and causes 125,000 deaths each year, including more than 15,000 in the U.S. The cancer is particularly difficult to treat because it usually found after it has already spread to other organs. Surgery can remove only some of the tumors, and the two chemotherapy drugs most commonly used aren't very good at killing the cancer cells left behind.

But the study results suggest that treatment for ovarian cancer could improve for the first time in 15 years, said Dr. Robert Burger, a surgical oncologist at Fox Chase Cancer Center and lead author for one of the studies.

"I think we finally have a third component of treatment that works differently and that may greatly complement our therapeutics for ovarian cancers," he said.

Avastin is a biological antibody that interferes with a growth factor that cancer cells need to grow new blood vessels. When used in concert with chemotherapy, the drug helps keep cancers that have metastasized from growing and spreading. The FDA has approved the drug for use in a number of different cancers, including non-small-cell lung, kidney, brain and colon cancer.

Most recently, its use in treating breast cancer has become a source of controversy, as the FDA last month withdrew its approval of Avastin for patients with advanced breast cancer because the modest benefits were not seen as outweighing the drug's side effects. Physicians, however, can still prescribe Avastin off-label.

Burger's team, known as the Gynecologic Oncology Group, looked at what's called progression-free survival ? the length of time before the cancer gets worse ? in 1,873 women with newly diagnosed stage III and stage IV ovarian cancers, which typically have 5-year survival rates ranging from 18% to 45%. The investigators found that patients who received Avastin throughout their chemotherapy treatment experienced 14.1 months of progression-free survival, compared with the 10.3 months for patients who received standard chemotherapy plus a placebo. (Patients who received Avastin only during the initial treatments had 11.2 months of progression-free survival.)

The second study, by the International Collaboration on Ovarian Neoplasms, looked at 1,528 ovarian cancer patients and found a smaller difference in progression-free survival ? 24.1 months for those who took Avastin versus 22.4 months for those who didn't.

But when they focused on the 465 patients with the most advanced cancers, they found a bigger benefit ? 14.5 months with standard therapy alone and 18.1 months with Avastin added. They also found that overall survival for these patients was better with Avastin, at 28.8 versus 36.6 months.

On the whole, however, the researchers said they would not able to say much about overall survival rates until the patients had been tracked for a few more years.

The studies documented some notable side effects from the drug, including an increased risk of hypertension and gastrointestinal wall disruption, when a hole develops in the gastrointestinal tract. But these problems did not affect patients' quality of life, both studies found.

Avastin does not come cheap. The drug, made by Genentech Inc., can cost about $50,000 to $100,000 a year, which may be a lot to pay for just a few months more of remission, said Dr. Joanne Mortimer, director of the Women's Cancers Program at the City of Hope Comprehensive Cancer Center in Duarte. Many insurance companies cover at least some of that cost.

"Is it worth it?" said Mortimer, who served on two of three FDA advisory panels that debated the use of Avastin for breast cancer. "These are positive studies, but are they meaningful differences?"

Though the answer for breast cancer was no, the answer for ovarian cancer may be different, she said. Drugs for breast cancer are held to a higher standard because much more is known about how to treat the disease. The bar is lower for ovarian cancer because the treatment options aren't as good, Mortimer said.

Dr. Timothy Perren, a medical oncologist at Spire Leeds Hospital in Yorkshire, England, who led the second study, said the trials were promising steps that would "cement the place of Avastin in treating ovarian cancer." But researchers from both groups noted that more work needed to be done to figure out which patients would benefit the most from the drug and the best way to administer it.

The studies were funded by the National Institutes of Health, the National Institute for Health Research in Britain, Genentech and its parent company, Roche.

amina.khan@latimes.com

Source: http://feedproxy.google.com/~r/latimes/news/nationworld/nation/~3/z4bMX1jbu4Y/la-he-avastin-ovarian-cancer-20111229,0,3960902.story

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grist: Top 10 clean energy stories of 2011 http://t.co/09bGsZgo

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Tatum, McConaughey's patriotic striptease

Feast your eyes on the men of "Magic Mike"!

In the first promo pic from the upcoming male stripper flick, Joe Manganiello, 34, Alex Pettyfer, 21, a shirtless (and newly engaged!) Matthew McConaughey, 42, and Channing Tatum, 31, perform a patriotic striptease.VIDEO: Channing Tatum's hilarious stripper video

The film, which stars Tatum as a veteran exotic dancer who mentors Pettyfer's character, is directed by Steven Soderbergh and also features Matt Bomer, Riley Keough and Olivia Munn. Magic Mike is loosely based off Tatum's experiences at a Chippendales-style revue.

VIDEO: Alex Pettyfer shows off his raunchy tattoos

"It's so funny," Manganiello, who plays Big Dick Richie, told The L.A. Times in October. "It's like 'Animal House' and 'Hangover' funny. Steven has most of it edited and he's such a good storyteller with that camera."

PHOTOS: Hollywood's buff boys

Magic Mike is expected to hit theaters in June 2012.

Copyright 2011 Us Weekly

Source: http://today.msnbc.msn.com/id/45804274/ns/today-entertainment/

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Scientists discover a brain cell malfunction in schizophrenia

Thursday, December 29, 2011

Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects.

The findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly.

The research, now available online in the new Nature journal, Translational Psychiatry, shows the deficit is especially pronounced in younger people, meaning treatment might be most effective early on at minimizing or even reversing symptoms of schizophrenia, a potentially devastating mental disorder associated with hallucinations, delusions, and emotional difficulties, among other problems.

"We're excited by the findings," said Scripps Research Associate Professor Elizabeth Thomas, a neuroscientist who led the study, "and there's a tie to other drug development work, which could mean a faster track to clinical trials to exploit what we've found."

A Promising New Field

Over the past few years, researchers have increasingly recognized that cellular-level changes not tied to genetic defects play important roles in causing disease. There is a range of such so-called epigenetic effects that change the way DNA functions without changing a person's DNA code.

One critical area of epigenetic research is tied to histones. These are the structural proteins that DNA has to wrap around. "There's so much DNA in each cell of your body that it could never fit in your cells unless it was tightly and efficiently packed," said Thomas. Histone "tails" regularly undergo chemical modifications to either relax the DNA or repack it. When histones are acetylated, portions of DNA are exposed so that the genes can be used. The histone-DNA complexes, known as chromatin, are constantly relaxing and condensing to expose different genes, so there is no single right or wrong configuration. But the balance can shift in ways that can cause or exacerbate disease.

DNA is the guide that cellular machinery uses to construct the countless proteins essential to life. If portions of that guide remain closed when they shouldn't because histones are not acetylated properly, then genes can be effectively turned off when they shouldn't be with any number of detrimental effects. Numerous research groups have found that altered acetylation may be a key factor in other conditions, from neurodegenerative disorders such as Huntington's disease and Parkinson's disease to drug addiction.

A Good Idea

Thomas had been studying the roles of histone acetylation in Huntington's disease and began to wonder whether similar mechanisms of gene regulation might also be important in schizophrenia. In both diseases, past research in the Thomas lab had shown that certain genes in sufferers were much less active than in healthy people. "It occurred to me that we see the same gene alterations, so I thought, 'Hey, let's just try it,'" she said.

Working with lead author Bin Tang, a postdoctoral fellow in her lab, and Brian Dean, an Australian colleague at the University of Melbourne, Thomas obtained post-mortem brain samples from schizophrenic and healthy brains held at medical "Brain Banks" in the United States and Australia. The brains come from either patients who themselves agreed to donate some or all of their bodies for scientific research after death, or from patients whose families agreed to such donations.

A great deal of epigenetic research has focused on chemical alterations to DNA itself. Histone alterations have been much more difficult to study because such research requires that the histones and DNA remain chemically intact. Many researchers feared that these bonds were disrupted in the brain after death. However, Thomas's group was able to develop a technique for maintaining the histone-DNA interactions. "While many people thought this was lost, we were able to show that indeed these interactions are preserved in post-mortem brain, allowing us to carry out these studies," said Thomas.

Compared to healthy brains, the brain samples from subjects with schizophrenia showed lower levels of acetylation in certain histone portions that would block gene expression. Another critical finding was that in younger subjects with schizophrenia, the problem was much more pronounced.

Need for New Treatment Options

Just what causes the acetylation defects among schizophrenic subjects?what keeps certain pages of the DNA guide closed?isn't clear, but from a medical perspective it doesn't matter. If researchers can reliably show that acetylation is a cause of the problem, they can look for ways to open the closed guide pages and hopefully cure or improve the condition in patients.

Thomas sees great potential. Based on the more pronounced results in younger brains, she believes that treatment with histone deacetylase inhibitors might well prove helpful in reversing or preventing the progression of the condition, especially in younger patients. Current drugs for schizophrenia tend to treat only certain symptoms, such as hallucinations and delusions, and the drugs have major side effects including movement problems, weight gain, and diabetes. If deacetylase inhibitors effectively treat a root cause of the disease and prove sufficiently non-toxic, they might improve additional symptoms and provide a major expansion of treatment options.

Interestingly, some of the cognitive deficits that plague elderly people look quite similar biologically to schizophrenia, and the two conditions share at least some brain abnormalities. So deacetylase inhibitors might also work as a treatment for age-related problems, and might even prove an effective preventive measure for people at high risk of cognitive decline based on family history or other indicators.

###

This study, "Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders," was supported by the National Institutes of Health. Samples were provided by the Harvard Brain Tissue Resource Center, and Australia's Victorian Brain Bank Network. For more information on the research, see http://www.nature.com/tp/journal/v1/n12/abs/tp201161a.html

Scripps Research Institute: http://www.scripps.edu

Thanks to Scripps Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116338/Scientists_discover_a_brain_cell_malfunction_in_schizophrenia

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Friday, December 30, 2011

tcdailyplanet: Five years in, University District Partnership celebrates successes in Southeast Minneapolis http://t.co/Hx8lyp1G

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Oscar ballots are in the mail (Reuters)

LOS ANGELES (TheWrap.com) ? The ballots are in the mail.

Ballots for the 84th Academy Awards were mailed to the nearly 6,000 Academy members on Tuesday, the Academy has announced. Those voters now have until January 13 to decide upon their favorite films, performances and/or accomplishments of the year, and to get their choices back to PricewaterhouseCoopers in time for a week and a half of detailed and complex counting.

The basics about the Oscar ballots that were mailed on Tuesday: They're color-coded by category, and cover 15 of the 24 Academy Awards categories. (Nominations in the rest of the categories are decided by special committees or at specific AMPAS events.)

Best Picture ballots are white, with the other categories using generally muted colors.

While Best Picture ballots are tabulated using the new system, the other 14 categories use the straight preferential count, which uses a number of rounds to narrow the field down to the final five nominees.

On every ballot except the acting ballot, voters are asked to list the name of the film, not the name of the person who will actually be nominated. This will make things much easier for directors who want to vote for Michel Hazanavicius but will only need to write "The Artist."

The reminder list of eligible films that accompanies most of the ballots includes film titles only, not names of potential nominees.

Members of the Actors Branch, though, are required to list the name of the actor and the name of the film -- and they're given complete leeway to decide if a performance belongs in the lead or supporting category (or even to put it in both if they're undecided).

If a performance actually gets enough votes to be nominated in both lead and supporting categories, it will receive the nomination in whichever category it drew the most support.

And given the way the system works, in only five categories does a film need more than 100 votes to be nominated for an Oscar. That's because nominations are made by the individual branches, not by the entire membership of the Academy.

The Actors Branch, with more than 1,100 members, is by far the largest. If every member were to vote, it would take just under 200 votes to secure a nomination in the four acting categories.

The next largest branches, the Producers Branch and the Executives Branch, with about 450 members each, only vote for Best Picture (as do Public Relations Branch members and Members at Large).

Directing, writing and sound categories require about 60 votes for a nomination; music requires about 40 for an Original Score nomination, with the Original Song category using a different process.

It goes all the way down to cinematography and film editing, which require between 30 and 40 votes, and makeup and hairstyling, which require only about 20 votes.

That doesn't seem like many for an Oscar nomination -- but remember, those are 20 top experts voting. It's the Academy's unofficial credo, when it comes to membership: quality, not quantity.

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/nm/20111227/film_nm/us_oscar_ballots

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Thursday, December 29, 2011

China's fiscal deficit to fall in 2012: source (Reuters)

SHANGHAI (Reuters) ? China's central government will run a smaller fiscal deficit in 2012, according to a report by local media.

Fiscal outlays will increase 11 percent to 11.1 trillion yuan ($1.75 trillion) in 2012, against a revenue increase of 9 percent, according an unnamed finance ministry source cited by the Shanghai Securities Journal.

The figures, which emerged at the conclusion of the national Ministry of Finance Work Meeting on Monday, imply a 2012 fiscal deficit of 800 billion yuan, down 50 billion yuan from the expected 2011 deficit, the paper calculated.

A smaller deficit would disappoint those hoping for robust stimulus by the government to support growth. Industrial production slowed to its slowest pace in four years in November.

Concerns about slowing growth prompted policymakers to lower the required reserve ratio for banks on December 5, but analysts believe authorities have limited space for additional monetary stimulus, given the flood of bank lending that resulted from the previous round in 2008-10.

The relatively healthy state of China's public finances raised hopes that China would use fiscal spending to support the economy in 2012.

For 2011, China's full-year fiscal revenue is on pace to reach 10.2 trillion yuan, a 22 percent increase over 2010, the source said, while spending will reach 11 trillion yuan, an increase of 20 percent.

Of next year's 800 billion yuan deficit, the central government's share will be 550 billion yuan, a decrease of 150 billion yuan, while the local government share will be 250 billion yuan, an increase of 50 billion yuan.

Local government spending will be fueled by an increase in direct bond issuance by local governments, the source said. ($1 = 6.3364 yuan)

(Reporting by Gabriel Wildau; Editing by Jonathan Hopfner)

Source: http://us.rd.yahoo.com/dailynews/rss/china/*http%3A//news.yahoo.com/s/nm/20111227/bs_nm/us_china_deficit

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Fitness and Health-Related Quality of Life Dimensions in Community-Dwelling Middle Aged and Older Adults.

Abstract

ABSTRACT:

BACKGROUND:

The aim of the present study was to identify the physical fitness (PF) tests of a multi-component battery more related to the perception of problems in each dimension of the health-related quality of life (HRQoL) assessed by the EuroQol 5 dimensions 3 level questionnaire (EQ-5D-3L) in community-dwelling middle-aged and older adults

METHODS:

A cross-sectional study was conducted with 7104 participants (6243 females and 861 males aged 50-99 years) who were recruited in the framework of the Exercise Looks After You Program, which is a public health program designed to promote physical activity (PA) in community-dwelling middle-aged and older adults. Participants were assessed by the EQ-5D-3L questionnaire and a battery of fitness tests. The responses to each EQ-5D-3L dimension were collapsed into a two-tier variable consisting of "perceive problems" and "do not perceive problems". Correlation coefficients for the relationships between the HRQoL variables, between the PF variables, and between the HRQoL and PF variables were obtained. Two logistic regression models, one adjusted and one unadjusted, were developed for each EQ-5D-3L dimension.

RESULTS:

There were significant correlations between all variables except anxiety/depression and the back scratch test. The PF tests that correlated best with the HRQoL dimensions were the Timed Up-and-Go Test (TUG) and the 6-min walk; pain/discomfort and anxiety/depression correlated less well. All PF tests correlated, especially the TUG and 6-min walk tests. Unadjusted logistic models showed significant goodness of fit for the mobility and pain/discomfort dimensions only. Adjusted logistic models showed significant goodness of fit for all dimensions when the following potential confounding variables were included: age, gender, weekly level of PA, smoking and alcohol habits, body mass index, and educational level. For all dimensions, the highest odds ratios for the association with PF tests were with the TUG; this was observed with both the unadjusted and adjusted models.

CONCLUSIONS:

The perception of problems, as measured by the EQ-5D-3L dimensions, was associated with a lower level of fitness, particularly for those dimensions that relate more closely to physical components. The PF tests that associated most closely with the perception of problems in the HRQoL dimensions were the TUG and the 6-min walk. This information will aid the design and assessment of PA programs that aim to improve HRQoL.

Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=22192520&dopt=Abstract

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Wednesday, December 28, 2011

Sinead O'Connor and Barry Herridge: It's Already Over!


In sad news today, Sinead O'Connor and Barry Herridge are getting divorced.

If it seems like they just got married, it's because they did. On December 9!

It was a great 18-day run for the couple. To put that in perspective, Kim Kardashian's marriage to Kris Humphries lasted four times longer than these two.

Why the change of heart, Sinead? The singer explained on her website:

Sinead O'Connor, Husband

"Dear friends, I had for reasons u (sic) will all understand, wished to keep this private but have been told today it is to be leaked in the next few days despite my best efforts ... So I must now leak it myself so as the record is straight."

"Within 3 hours of the ceremony being over the marriage was kyboshed by the behaviour of certain people in my husband's life. And also by a bit of a wild ride I took us on looking for a bit of a smoke of weed for me (sic) wedding night as I don't drink."

"My husband was enormously wounded and very badly effected (sic) by that experience and also by the attitude of those close to him toward our marriage."

"It became apparent to me that if he were to stay with me he would be losing too much to bear... A woman wants to be a joy to her husband."

"So... U (sic) love someone? Set them free."

Words to live by, people. Words to live by.

[Photo: WENN.com]

Source: http://www.thehollywoodgossip.com/2011/12/sinead-oconnor-and-barry-herridge-its-already-over/

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Egyptian Women Get Another Win with 'Virginity Test' Ban (The Atlantic Wire)

Woman today in Egypt won a right that they obviously should have had all along after an Egyptian court banned the administration of "virginity tests" on female prisoners, reports MSNBC and CNN. The officially given reason why?the government needs to know whether or not its detainees have had sex is beyond our comprehension, ostensively to "safeguard against the women accusing authorities of sexual assault," according to CNN. But the real motive seems obvious to us, and to Samira?Ibrahim, a 25-year-old Egyptian?pictured to the right above who sued the government after she was forced to have a virginity test after being arrested in March: "degrade the protesters."?

Related: Four New York Times Reporters Missing in Libya

Today, though, we're happy with the refreshing feminist voice heard in the new unrest in Egyptian, a region where women often don't have much of a chance to make themselves heard. Last week thousands of Egyptian women took to the streets?after the now-famous blue-bra-woman beating. Consider this another win for Egyptian women.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/atlantic/20111227/wl_atlantic/egyptianwomengetanotherwinvirginitytestban46682

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Tuesday, December 27, 2011

NBA Commish Stern opens season with boos in Dallas

? NBA Commissioner David Stern opened his lockout-delayed season by hearing boos from fans.

Stern was in Dallas for the NBA finals rematch between the Mavericks and Heat, and he was on the court for the start of the Mavs' banner-raising ceremony honoring their first championship. The jeers came as soon as he started speaking, but he quickly turned them into cheers by offering his congratulations to team owner Mark Cuban.

Cuban's often contentious relationship with Stern could've been as much of a reason for the boos as the lockout, which pushed the opener from Nov. 1 to Christmas and cut the season by 16 games.

Cuban and Miami's Mickey Arison were among five owners who voted against the labor deal. Stern downplayed that, hailing the agreement as beneficial to everyone.

The Associated Press

Source: http://www.signonsandiego.com/news/2011/dec/25/nba-commish-stern-opens-season-with-boos-in-dallas/

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Rapture Or Not, Promise To Care For Pets Stands | KOSU Radio

Filed by KOSU News in Business.
December 24, 2011

Back in May, followers of Harold Camping were preparing for the coming rapture. For some, that preparation included someone to look after their pets.

At the time, animal lover Bart Centre, the creator of Eternal Earth-Bound Pets, had 259 clients whose pets he promised to look after in the event that they were raptured in the next 10 years. Those clients paid $135 for the first pet and $20 for each additional pet.

Clearly, the rapture didn?t happen as predicted on May 21. Centre tells weekends on All Things Considered host Guy Raz that, with the exception of a few demands for refunds, there wasn?t a lot of fallout from the religious event, or nonevent, rather.

?I had to disappoint them and let them know we don?t do refunds,? Centre says.

There might not have been much fallout to Centre?s business from the rapture not happening, but there was some fallout, in the form of complaints, when NPR first told Centre?s story. Many criticized him and said that he was taking advantage of people, but Centre says that?s not the case.

?I do not advertise my business. My business is advertised by the media and by word of mouth,? Centre says. ?I don?t threaten people with the rapture coming; I outright tell them I do not believe in the rapture.?

Centre says that does not negate the possibility that they could be right and he could be wrong, so he?s offering a service to people who love their pets and believe the rapture is going to happen.

?I?m not in a position to say to them, ?It?s not going to happen and you?re foolish,?? he says. ?If this is what they believe, then I will give them piece of mind.?

Centre says business has been a little slow and he?s added only a few clients since May. But he expects that around October 2012, close to when the Mayan calendar ends and what many people believe signifies the coming rapture, business might just pick up again. [Copyright 2011 National Public Radio]

Source: http://kosu.org/2011/12/rapture-or-not-promise-to-care-for-pets-stands/

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Monday, December 26, 2011

Unprovoked attacks at heart of 'Knockout King'

In this Dec. 15, 2011 photo, Matt Quain poses for a portrait in St. Louis. Quain still struggles to piece together what happened after a recent trip to the grocery store nearly turned deadly when he was the victim of a brutal attack generally known as "Knockout King" or simply "Knock Out," a so-called game of unprovoked violence that targets random victims. (AP Photo/Jeff Roberson)

In this Dec. 15, 2011 photo, Matt Quain poses for a portrait in St. Louis. Quain still struggles to piece together what happened after a recent trip to the grocery store nearly turned deadly when he was the victim of a brutal attack generally known as "Knockout King" or simply "Knock Out," a so-called game of unprovoked violence that targets random victims. (AP Photo/Jeff Roberson)

(AP) ? Matthew Quain still struggles to piece together what happened after a trip to the grocery store nearly turned deadly. He remembers a group of loitering young people, a dimly lit street ? then nothing. The next thing he knew he was waking up with blood pouring out of his head.

The 51-year-old pizza kitchen worker's surreal experience happened just before midnight earlier this year, when he became another victim of what is generally known as "Knockout King" or simply "Knock Out," a so-called game of unprovoked violence that targets random victims.

Scattered reports of the game have come from around the country including Massachusetts, New Jersey and Chicago. In St. Louis, the game has become almost contagious, with tragic consequences. An elderly immigrant from Vietnam died in an attack last spring.

The rules of the game are as simple as they are brutal. A group ? usually young men or even boys as young as 12, and teenage girls in some cases ? chooses a lead attacker, then seeks out a victim. Unlike typical gang violence or other street crime, the goal is not revenge, nor is it robbery. The victim is chosen at random, often a person unlikely to put up a fight. Many of the victims have been elderly. Most were alone.

The attacker charges at the victim and begins punching. If the victim goes down, the group usually scatters. If not, others join in, punching and kicking the person, often until he or she is unconscious or at least badly hurt. Sometimes the attacks are captured on cellphone video that is posted on websites.

"These individuals have absolutely no respect for human life," St. Louis Mayor Francis Slay said.

Slay knows firsthand. He was on his way home from a theater around 11:30 p.m. on Oct. 21 when he saw perhaps a dozen young people casually crossing a street. He looked to the curb and saw Quain sprawled on the pavement.

Slay told his driver to pull over. They found Quain unconscious, blood pouring from his head and mouth.

Quain was hospitalized for two days with a broken jaw, a cracked skull and nasal cavity injuries. He still has headaches and memory problems but was finally able to return to work earlier this month. Hundreds gathered in November for a fundraiser at the restaurant where he works, Joanie's Pizza, but he still doesn't know how he'll pay the medical bills.

"I don't remember much of what happened," Quain said. "I was hanging out with a friend, celebrating the Cardinals in the World Series. I went to the store and saw a group of kids who looked out of place, suspicious, but I shrugged it off. I got around to the library, and the next thing I remember is waking up on the corner with the mayor standing next to me. I tried to say 'hi' but my jaw was broken."

It isn't clear how long Knockout King has been around, nor is the exact number of attacks known. The FBI doesn't track it separately, but Slay said he has heard from several mayors about similar attacks and criminologists agree versions of the game are going on in many places.

St. Louis Police Chief Dan Isom said the city has had about 10 Knockout King attacks over the past 15 months.

Experts say it is a grab for attention.

"We know that juveniles don't think out consequences clearly," said Beth Huebner, an associate professor of criminology at the University of Missouri-St. Louis. "They see something on YouTube and say, 'I want to get that sort of attention, too.' They don't think about the person they're attacking maybe hitting their head."

Scott Decker, a criminologist at Arizona State, said the attacks are a modern extension of gang-like behavior ? instead of painting over another gang's graffiti as a show of toughness, they beat someone up and post a video on social media sites. The postings spur copycat crimes.

"It's adolescent and early adults, largely male, showing how tough they are. It's done to show off," Decker said.

Earlier this year in Chicago, a group of teens followed an elderly homeless man at a train station. One of the teens walked up to him and punched him in the face, knocking him out as the teen's friends laughed and mocked the man. The exchange was captured on video and posted on a hip-hop site, where it got about a quarter of a million views within two days. The teen was not arrested because police couldn't locate the homeless man to see if he wanted to press charges.

The crimes aren't limited to big cities. In 2009, Adam Taylor had just entered a parking garage in Columbia, Mo. Surveillance footage from the garage showed a group of teens following him. One of the teens attacked, punching Taylor and sending him crashing into a brick wall. A few seconds later, the others joined in, punching and kicking him as he lay on the ground. Taylor suffered bruising on the brain, whiplash and internal bleeding but survived.

Hoang Nguyen wasn't as fortunate.

The 72-year-old retired schoolteacher immigrated to St. Louis from Vietnam with his wife less than four years earlier to be near their daughter. The couple was returning to their apartment after walking to a grocery store on an April morning in broad daylight.

They took a shortcut through an alley, where they saw a group of young people approaching. Suddenly, one of them charged. Hoang was attacked as he stepped in front of his wife to protect her. The attack went on as he begged for mercy, she told police.

Hoang died of massive injuries. Elex Murphy, 18, was charged with first-degree murder and allegedly told police the attack was part of the Knockout King game. His attorney declined to comment.

St. Louis authorities are going to the source to combat further attacks. A special police squad has been assigned to focus on Knockout King, and a city prosecutor is designated for the attacks. But Isom said equally important is an outreach effort to talk to students.

"Certainly we take this very seriously and we're making every effort to stop it," Isom said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-12-24-Thrill%20Assaults/id-ec1b19d37a334c6e909beb03e1b6237f

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allezlesbleusca: RT @chatfootball: http://t.co/Ck4zrTRN Class 2012: Kent prep (USA) Linebacker/Tight End Pierre-Luc Caron undecided between CIS or NCAA ( ...

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Sunday, December 25, 2011

Tournament of THG: Last Chance to Vote in Quarterfinal Matchups!


Welcome back to the Tournament of THG, where fans vote on the most popular star of 2011! The concept is simple: Pick your favorite of the two stars in each poll. Done.

The semifinal round (final four) starts Monday, so this is your last chance to cast a virtual ballot in all four quarterfinal contests. So far, some are closer than others.

Katy Perry, Demi Lovato, Robert Pattinson and Miley Cyrus are ahead at the moment, but that could all change with a late surge. Only time - and you - will tell!

Who will advance to the next round? VOTE below (and after the jump)!

Source: http://www.thehollywoodgossip.com/2011/12/tournament-of-thg-last-chance-to-vote-in-quarterfinal-matchups/

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Golf & Zola's Lounge: Merry christmas to you all :-)

football O.S latest bones 45 2,043 25 Dec 00:57 football John Terry... georgewhufc 29 1,077 25 Dec 00:51 football time to get rid of big fat sam KetterinHammer 41 1,361 25 Dec 00:44 football Birmingham v West Ham Official Match Thread Boleyn_Boy 12 358 25 Dec 00:38 football The Official 'Fat Sam's Head' thread Tone_Loc 4 283 24 Dec 16:31 football As January Approaches... FLAIRON 23 778 24 Dec 14:55 football PREDICTION LEAGUE ROUND 23 Landsbanki 21 276 24 Dec 14:54 football coyle and keans turn hightec 22 1,131 24 Dec 10:20 football Thursday Night Footy USAFORWHUFC 12 516 24 Dec 02:12 football Pardew gazhammer 15 566 24 Dec 00:31 football Transferred: Merry Christmas? frenchlion 0 351 24 Dec 00:19 football Hall recalled from loan .. Again! HomerHammer 15 658 23 Dec 17:30 football Demba Ba castiron 21 958 23 Dec 15:23 football keeper fights with fan ! noryhead 8 550 23 Dec 12:02 football West Ham Xmas party last night in Dublin hightec 19 1,251 23 Dec 10:20 football looking a bit dodgy for the northerners! dagenhamJohn 5 497 23 Dec 10:06 football Is it just me... Bryan_pop_robson 19 581 23 Dec 09:59 football Breaking WHU news!! hightec 44 2,097 23 Dec 09:54 football Fat Frank auditions to be on LFC TV hightec 0 198 22 Dec 08:58 football pompy likemydreams 1 483 22 Dec 02:18 football merry christmas alfinyalcabo 0 164 21 Dec 18:37 football Breaking News... Ironsides 2 739 21 Dec 15:07 football Here we go hightec 12 1,500 21 Dec 10:51 football whu news hightec 8 1,241 21 Dec 06:49 football Pablo Barrera HomerHammer 6 926 20 Dec 19:43 football Wolds Stupidest Goalkeeper ucanfart 6 517 20 Dec 19:22 football Tony Carr clemmo 2 365 20 Dec 17:06 football Has the development squad got a technological advantage? BillyDWhizz 0 240 20 Dec 16:41 football you ready for it hightec 4 580 20 Dec 14:20 football Montano extends Daggers deal HomerHammer 9 397 20 Dec 11:48 football Has Carton got the Xmas X factor HomerHammer 0 304 20 Dec 11:40 football Final Championship Table Prediction Game Entries Landsbanki 187 497 20 Dec 11:08 football Saints fan here harvey_7 7 829 20 Dec 09:30 football Official Sam Allardyce January 2012 Transfer Rumours Thread Razor_Ironz 51 2,917 20 Dec 07:48 football Man of the match... steveytastic 28 1,447 20 Dec 07:33 football What Do We Mean By "Fair Weather" Fans? Whiskyman 13 450 19 Dec 21:17 football Forest Fan In Peace... gazd1980 1 385 19 Dec 21:04 football Colchester vs Dev squad 7pm ko HomerHammer 1 222 19 Dec 20:58 football Fat sam talking about yesterdays game. bones 24 1,001 19 Dec 20:28 football Legal stream for Boxing Day game (Finland) HammerJammer 0 128 19 Dec 20:23 football Best own goal ever - Fact 0ziron 3 295 19 Dec 18:40 football Transferred: Kim Jong (our glorious r? hightec 0 388 19 Dec 17:31 football Players On Loan--Just A Thought. Whiskyman 1 258 19 Dec 14:56 football Lost interest due ugly football Kovalchuk 77 1,955 19 Dec 11:55 football Bubbles and Ironworks Playoffzz 13 660 19 Dec 11:07 football WHU v Barnsley goal and highlights here bazwillrun 3 459 19 Dec 10:04 football Dan Potts. steviediv1 0 233 19 Dec 09:12 football noble out zamora in ironside8586 10 726 19 Dec 09:00 football Was just thinking... happyhammer4eva 13 732 18 Dec 18:57 football Halfway point CALI66HAMMER 2 479 18 Dec 11:25 football West ham v Barnsley official match thread farnboroughhammer 78 1,154 18 Dec 08:10 football PREDICTION LEAGUE ROUND 22 Landsbanki 25 512 18 Dec 02:23 football west ham stream mrbubbles 4 405 17 Dec 16:54 football West Ham make move to sign Barcelona striker mrbubbles 7 887 17 Dec 01:34 football Fat Sam talking about new players. bones 0 489 16 Dec 17:54 football Couple of spare hours?...poll on premier leagues best goal chickenrun66 3 175 16 Dec 12:58 football Underground cavhammer 10 547 16 Dec 12:39 football guess the team greenshouldbe1 3 299 16 Dec 12:38 football Saggy chops vs the paddys eaststandpete 4 424 16 Dec 11:58 football oh dear hightec 1 374 16 Dec 11:48

Source: http://boards.footymad.net/forum.php?tno=551&fid=414&act=1&mid=2115681195

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